#5 Hemophilia A Disorder

1. Hemophialia A is a a hereditary bleeding disorder caused by a lack of blood clotting factor VIII. Without enough factor VIII, the blood cannot clot properly to stop bleeding.

2. Hemophilia A is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. Females have two copies of the X chromosome, so if the factor VIII gene on one chromosome doesn't work, the gene on the other chromosome can do the job of making enough factor VIII. Males, however, have only one X chromosome, so if the factor VIII gene on that chromosome is defective, they will have hemophilia A. Thus, most people with hemophilia A are male.

3. Men, and Women after giving birth.

4. Hemophilia causes bleeding and bruising. This can lead to internal bleeding and painful swelling of the joints. Septic arthritis occurs more frequently in people with hemophilia. Abdominal bleeding and digestive problems are concerns in people with hemophilia. Bleeding can cause skin discoloration, pain, and swelling under the skin.

5. Standard treatment involves replacing the missing clotting factor. The amount of factor VIII concentrates needed depends on the severity of the bleeding, the site of the bleeding, and the size of the patient.

6. Hemophilia is a genetic (inherited) disease and cannot be prevented. Genetic counseling, identification of carriers through molecular genetic testing, and prenatal diagnosis are available to help individuals understand their risk of having a child with hemophilia.

7. 30 years ago, the life expectancy for a hemophiliac was short approximately 40-50 years but now scientists rocking with recombinant DNA technology which increases the quality of life span.

http://youtu.be/BZN9skFmKTg